Synthesis, characterization and molecular docking study of novel N-substituted sulfadiazine derivatives as potential anti-mycobacterial agents
By: Khan, Ayad Kareem
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Contributor(s): Razik, Basma M. Abd.
Publisher: New Delhi CSIR 2022Edition: Vol.61(6), Jun.Description: 671-677p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: A new series N-substituted sulfadiazine derivatives attached with different heterocyclic rings such as 4-oxo-1, 4-dihydroquinazolin[7-12], 4-oxo-2H-benzo[1,3]thiazin[13-18] have been synthesized by condensation reactions. The structures of synthesized derivatives are characterized by FT-IR, 1H-NMR, 13C-NMR spectroscopic techniques, and some physicochemical properties. A molecular docking study is performed and the binding values show very good matching with experimentally result. The present work deals with newly synthesized sulfadiazine derivatives that are screened for their (In-vitro) antitubercular activity of compounds [7-18] is carried out against Mycobacterium tuberculosis H37Rv. compounds [8,11,13,14,15,17] are found most active (MIC=4-16 µg/mL) and compounds [7, 9,10,12,16,18] are found good to moderately active (MIC = 62.5-125 µg/mL) by using isoniazid as standard drug.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2023-0768 |
A new series N-substituted sulfadiazine derivatives attached with different heterocyclic rings such as 4-oxo-1, 4-dihydroquinazolin[7-12], 4-oxo-2H-benzo[1,3]thiazin[13-18] have been synthesized by condensation reactions. The structures of synthesized derivatives are characterized by FT-IR, 1H-NMR, 13C-NMR spectroscopic techniques, and some physicochemical properties. A molecular docking study is performed and the binding values show very good matching with experimentally result. The present work deals with newly synthesized sulfadiazine derivatives that are screened for their (In-vitro) antitubercular activity of compounds [7-18] is carried out against Mycobacterium tuberculosis H37Rv. compounds [8,11,13,14,15,17] are found most active (MIC=4-16 µg/mL) and compounds [7, 9,10,12,16,18] are found good to moderately active (MIC = 62.5-125 µg/mL) by using isoniazid as standard drug.
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